Biological Activity of sym-Triazines with Acetylcholine-like Substitutions as Multitarget Modulators of Alzheimer's Disease
Veloso AJ, Chow AM, Dhar D, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K
Two novel sym-triazine derivatives were demonstrated as promising candidates against Alzheimer’s disease, supported by their capabilities in modulation of amyloid-β (Aβ1-42) fibril formation and inhibition of acetylcholinesterase activity. The cover figure shows that these sym-triazine derivatives were well tolerated and have potential beneficial effects on human neurons, promoting differentiation and extension of neurite processes, as highlighted with the cytoskeleton marker protein α-tubulin (green), and upregulating expression of the synaptic marker protein synaptophysin (red, indicated by white box). Art designers: Ari M. Chow and Anthony J. Veloso.