I am interested in understanding the neural circuit mechanisms of behavioural development. Animals develop increasingly sophisticated behaviours after birth. Addressing the underlying mechanisms of circuit maturation in the brain is fundamental to understanding how neural circuits develop, are functionally organized, and operate. In addition, insights gained will provide a platform to aid our understanding of developmental brain disorders. We use zebrafish, an optically and genetically accessible model vertebrate that enables us to examine how circuit elements emerge, form circuitry, and contribute to behaviour across development through powerful combinations of optics, physiology, genetics and behavioural analys
My lab currently focuses on the circuit mechanisms of the development of sophisticated motor coordination. We are examining the circuit maturation in the hindbrain and the spinal cord that control the executive element of motor behaviours, using cutting-edge techniques such as two-photon optogenetics circuit mapping, voltage imaging, CRISPR/Cas9-based cell-type targeting and lineage tracing, photo-inducible cell ablation, and machine-learning-based behavioural analyses.
We are currently recruiting graduate students and postdoctoral fellows. Please inquire via email.