Projects

University of Toronto at Scarborough | Department of Environmental and Physical Science

Copyright© 2017 Kerman Group

Our current projects range from post-translational protein modifications, drug screening for neurodegenerative diseases to the synthesis of bioconjugates using nanomaterials.

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Project List

Failure to regulate apoptosis is a common feature in several diseases including autoimmune disorders, neurodegenerative diseases, cancer and AIDS. Our research aims to understand the two main pathways for the induction of apoptosis, the extrinsic or receptor-mediated pathway, and the intrinsic or mitochondrial pathway.

Alzheimer’s disease is the principal cause of senile dementia. The fibrillation of amyloid-β peptides is investigated using electrochemical and optical techniques. The effect of metal ions on the fibrillation process of the peptides sheds a light on the development of possible therapeutics.

Carbon nanotubes, metal nanoparticles and quantum dots are conjugated with aptamers and lectins for the detection of biochemical events on solid surfaces.

Electrochemical mechanisms for the oxidation and reduction of nucleic acids and proteins on solid and mercury electrodes are investigated towards a better understanding of their interactions with drugs, metals and other biomolecules.

Biosensing the programmed cell death (Apoptosis)

Bioconjugates of nanoparticles

Biosensing neurodegenerative diseases

Electrochemistry of nucleic acids and proteins

Disposable biosensors are developed for the on-field determination of environmentally hazardous compounds and bacteria. Enzymes, nucleic acids and peptides are used as the biorecognition layers on solid surfaces.

 

Biosensors for environmental monitoring

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Kerman Laboratory

University of Toronto at Scarborough